Arizono-Shimada, Keira; Hotokezaka, Hitoshi; Morita, Yukiko; Ino-Kondo, Airi; Ueda-Ichinose, Yuika; Nashiro, Yukako; Hotokezaka, Yuka; Yoshimi, Keiko; Kiliaridis, Stavros; Yoshida, Noriaki (2022). The effect of masseter muscle mass on the rate of experimental tooth movement in rats. Journal of oral rehabilitation, 49(10), pp. 1012-1019. Wiley 10.1111/joor.13357
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J_of_Oral_Rehabilitation_-_2022_-_Arizono_Shimada_-_The_effect_of_masseter_muscle_mass_on_the_rate_of_experimental_tooth.pdf - Accepted Version Available under License Publisher holds Copyright. Download (687kB) | Preview |
BACKGROUND
Previous clinical observational studies have suggested that orthodontic tooth movement (OTM) is related, at least partly, to the mass and/or capabilities of the masticatory muscles.
OBJECTIVES
Our study aimed to examine the influence of masticatory muscle mass on the OTM in an animal experimental model in which the masseter muscle was modulated by botulinum neurotoxin type A (BTX) injection.
METHODS
Eighteen Wistar rats were equally divided into two groups: BTX injection and control. BTX was injected bilaterally into the masseter muscles. Three days after the injection, the maxillary left first molars were orthodontically moved for 14 days. At the end of the experiment, micro-computed tomography was performed to evaluate the rate of OTM and bone morphometry. The masseter muscles were weighed and prepared for histological analyses.
RESULTS
The masseter muscle mass in the BTX group was less than that in the control group, and histological findings showed atrophy of muscle fibers. The rate of OTM was significantly higher in the BTX group than in the control group. Furthermore, a negative correlation was detected between masseter muscle mass and OTM in the BTX group. Bone morphometry showed no difference between the control and BTX groups.
CONCLUSION
Decreased masseter muscle mass was found to be closely related to an increase in the rate of OTM in rats using BTX injection to modify the masseter muscle mass. Masseter muscle mass could be a predictive factor for OTM in rats injected with BTX.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics |
UniBE Contributor: |
Kiliaridis, Stavros |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1365-2842 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Jul 2022 11:38 |
Last Modified: |
17 Jul 2023 00:25 |
Publisher DOI: |
10.1111/joor.13357 |
PubMed ID: |
35842739 |
Uncontrolled Keywords: |
bone morphometry botulinum neurotoxin type A masseter muscle masticatory muscle micro-computed tomography orthodontic tooth movement |
BORIS DOI: |
10.48350/171356 |
URI: |
https://boris.unibe.ch/id/eprint/171356 |
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