Prognostic Role of RNA Expression Molecular Biomarkers in Prostate and Bladder Cancers.

Ahmed, Mohamed E; Todenhöfer, Tilman; Karnes, R Jeffrey; Seiler, Roland (2022). Prognostic Role of RNA Expression Molecular Biomarkers in Prostate and Bladder Cancers. European urology focus, 8(3), pp. 663-666. Elsevier 10.1016/j.euf.2022.06.009

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Prostate cancer and bladder cancer are two of the most common urologic cancers. Cancer risk stratification and prediction of prognosis have always been challenging. Following recent advances in genomic and proteomic technologies, several genomic biomarkers have been developed and proposed as a noninvasive and nonexpansive approach that can supplement our current data to improve prediction and accuracy. Several biomarkers have shown efficacy in patient risk stratification and in predicting prognosis. Here we provide a mini-review of current RNA biomarkers approved by the US Food and Drug Administration, including the Decipher, Oncotype DX Prostate, and Prolaris tests. We also provide a summary of their approved clinical utility in prostate cancer and bladder cancer management. PATIENT SUMMARY: A number of tests are available for measuring expression levels of genes related to prostate or bladder cancer. We review the usefulness of these tests in stratifying risk for patients and predicting their prognosis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie

UniBE Contributor:

Seiler-Blarer, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2405-4569

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

20 Jul 2022 11:32

Last Modified:

31 Aug 2022 00:15

Publisher DOI:

10.1016/j.euf.2022.06.009

PubMed ID:

35843864

Uncontrolled Keywords:

Biomarkers Bladder cancer Decipher Oncotype DX Prolaris Prostate cancer RNA biomarkers

BORIS DOI:

10.48350/171419

URI:

https://boris.unibe.ch/id/eprint/171419

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