Enabling non-isocentric dynamic trajectory radiotherapy by integration of dynamic table translations.

Guyer, Gian; Mueller, Silvan; Koechli, Carole; Frei, Daniel; Volken, Werner; Bertholet, Jenny; Mackeprang, Paul-Henry; Loebner, Hannes A; Aebersold, Daniel M; Manser, Peter; Fix, Michael K (2022). Enabling non-isocentric dynamic trajectory radiotherapy by integration of dynamic table translations. Physics in medicine and biology, 67(17) Institute of Physics Publishing IOP 10.1088/1361-6560/ac840d

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OBJECTIVE

The purpose of this study is to develop a treatment planning process (TPP) for non-isocentric dynamic trajectory radiotherapy (DTRT) using dynamic gantry rotation, collimator rotation, table rotation, longitudinal, vertical and lateral table translations and intensity modulation and to validate the dosimetric accuracy.

APPROACH

The TPP consists of two steps. First, a path describing the dynamic gantry rotation, collimator rotation and dynamic table rotation and translations is determined. Second, an optimization of the intensity modulation along the path is performed. We demonstrate the TPP for three use cases. First, a non-isocentric DTRT plan for a brain case is compared to an isocentric DTRT plan in terms of dosimetric plan quality and delivery time. Second, a non-isocentric DTRT plan for a craniospinal irradiation (CSI) case is compared to a multi-isocentric intensity modulated radiotherapy (IMRT) plan. Third, a non-isocentric DTRT plan for a bilateral breast case is compared to a multi-isocentric volumetric modulated arc therapy (VMAT) plan. The non-isocentric DTRT plans are delivered on a TrueBeam in developer mode and their dosimetric accuracy is validated using radiochromic films.

MAIN RESULTS

The non-isocentric DTRT plan for the brain case is similar in dosimetric plan quality and delivery time to the isocentric DTRT plan but is expected to reduce the risk of collisions. The DTRT plan for the CSI case shows similar dosimetric plan quality while reducing the delivery time by 45% in comparison with the IMRT plan. The DTRT plan for the breast case showed better treatment plan quality in comparison with the VMAT plan. The gamma passing rates between the measured and calculated dose distributions are higher than 95% for all three plans.

SIGNIFICANCE

The versatile benefits of non-isocentric DTRT are demonstrated with three use cases, namely reduction of collision risk, reduced setup and delivery time and improved dosimetric plan quality.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Guyer, Gian Mauro Carlo; Mueller, Silvan; Frei, Daniel; Volken, Werner; Bertholet, Jenny; Mackeprang, Paul-Henry; Löbner, Hannes Anton; Aebersold, Daniel Matthias; Manser, Peter and Fix, Michael

Subjects:

500 Science > 530 Physics
600 Technology > 610 Medicine & health

ISSN:

0031-9155

Publisher:

Institute of Physics Publishing IOP

Language:

English

Submitter:

Pubmed Import

Date Deposited:

27 Jul 2022 10:39

Last Modified:

26 Sep 2022 11:24

Publisher DOI:

10.1088/1361-6560/ac840d

PubMed ID:

35878610

Uncontrolled Keywords:

Direct aperture optimization Dynamic Trajectory Radiotherapy Multi-isocentric treatment techniques

BORIS DOI:

10.48350/171524

URI:

https://boris.unibe.ch/id/eprint/171524

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