Effects of Roux-en-Y gastric bypass and sleeve gastrectomy on β-cell function at one year after surgery: a systematic review [meta-analysis].

Buser, Angeline; Joray, Chloé; Schiavon, Michele; Kosinski, Christophe; Minder, Beatrice; Nakas, Christos T.; Dalla Man, Chiara; Muka, Taulant; Herzig, David; Bally, Lia (2022). Effects of Roux-en-Y gastric bypass and sleeve gastrectomy on β-cell function at one year after surgery: a systematic review [meta-analysis]. The journal of clinical endocrinology and metabolism, 107(11), pp. 3182-3197. Oxford University Press 10.1210/clinem/dgac446

[img]
Preview
Text
Buser_JClinEndocrinolMetab_2022.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (1MB) | Preview
[img]
Preview
Text
dgac446.pdf - Accepted Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (2MB) | Preview

Bariatric surgery is a highly effective obesity treatment resulting in substantial weight loss and improved glucose metabolism. We hereby aimed to summarize available evidence of the effect of the two most common bariatric surgery procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), on dynamic measures of β-cell function (BCF). A systematic search of the literature was conducted in 3 bibliographic databases for studies reporting effects of RYGB and/or SG on BCF assessed using dynamic metabolic perturbation (oral or intravenous bolus stimulation), performed before and 1 year (± 3 months) after surgery. Twenty-seven unique studies (6 randomized controlled trials and 21 observational studies), involving a total of 1,856 obese adults were included for final analysis. 25 and 9 studies report effects of RYGB and SG on BCF respectively (7 studies compared the two procedures). 7 studies report results according to pre-surgical diabetic status. Owing to variable testing procedures and BCF indices reported, no meta-analysis was feasible, and data were summarized qualitatively. For both surgical procedures, most studies suggest an increase in BCF and disposition index, particularly when using oral stimulation, with a more pronounced increase in diabetic than non-diabetic individuals. Additionally, limited indications for greater effects after RYGB and SG was found. The quality of the included studies was in general satisfactory. The considerable heterogeneity of test protocols and outcome measures underscores the need for a harmonization of BCF testing in future research.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry
13 Central Units > Administrative Director's Office > University Library of Bern

UniBE Contributor:

Joray, Chloé Jacqueline, Kosinski, Christophe, Minder, Beatrice, Nakas, Christos T., Muka, Taulant, Herzig, David, Bally, Lia Claudia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
000 Computer science, knowledge & systems > 020 Library & information sciences

ISSN:

1945-7197

Publisher:

Oxford University Press

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Pubmed Import

Date Deposited:

29 Jul 2022 15:32

Last Modified:

05 Dec 2022 16:22

Publisher DOI:

10.1210/clinem/dgac446

Related URLs:

PubMed ID:

35895383

Additional Information:

Buser and Joray contributed equally to this work (first-authorship); Herzig and Bally equally contributing last-authorship.

Uncontrolled Keywords:

Roux-en-Y gastric bypass bariatric surgery disposition index obesity sleeve gastrectomy β-cell function

BORIS DOI:

10.48350/171584

URI:

https://boris.unibe.ch/id/eprint/171584

Actions (login required)

Edit item Edit item
Provide Feedback