Ramírez Mena, Adrià; Ngom, Ndeye Fatou; Tine, Judicaël; Ndiaye, Kine; Fortes, Louise; Ndiaye, Ousseynou; Fall, Maguette; Gaye, Assietou; Ka, Daye; Seydi, Moussa; Wandeler, Gilles (2022). Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal. Viruses, 14(8), p. 1614. MDPI 10.3390/v14081614
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Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%-15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%-12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (p = 0.07). An HBV viral load > 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04-3.66). Male participants (aOR 4.32, 95% CI 2.01-8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01-8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Ramírez Mena, Adrià, Wandeler, Gilles |
Subjects: |
300 Social sciences, sociology & anthropology > 360 Social problems & social services 600 Technology > 610 Medicine & health |
ISSN: |
1999-4915 |
Publisher: |
MDPI |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
02 Aug 2022 08:49 |
Last Modified: |
07 Aug 2024 15:45 |
Publisher DOI: |
10.3390/v14081614 |
PubMed ID: |
35893680 |
Uncontrolled Keywords: |
HIV Senegal hepatitis B hepatitis B viral load liver fibrosis |
BORIS DOI: |
10.48350/171592 |
URI: |
https://boris.unibe.ch/id/eprint/171592 |
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