Intrameningioma metastasis: A case-based literature review.

Papadakis, Benjamin Konstantinos; Vorrias, Eleftherios; Bräutigam, Konstantin; Chochlidakis, Nikolaos; Koutsopoulos, Anastasios; Mavroudis, Dimitrios; Vakis, Antonis; Tsitsipanis, Christos (2021). Intrameningioma metastasis: A case-based literature review. Journal of clinical neuroscience, 93, pp. 168-173. Elsevier 10.1016/j.jocn.2021.08.028

[img] Text
1-s2.0-S0967586821004471-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (282kB) | Request a copy

A tumor-to-tumor metastasis inside a meningioma is a rare phenomenon. Malignant neoplasms of the breast and lung are the most common primary tumors. Other sites of origin include prostate, renal and gastric neoplasms. The included case files were retrieved from the medical records of the University Hospital of Crete, Greece. A review of the literature was conducted in March 2020 via PubMed. Relevant search results were few. We report a case of a 66-year-old female, with known Small Cell Lung Cancer, who presented with left-sided hemiparesis. The Magnetic Resonance Imaging scan revealed a right frontal extra-axial mass. The patient underwent a craniotomy and a gross total removal of the tumor. Histological examination of the excised mass revealed metastatic adenocarcinoma deposits inside a meningioma: tumor-to-tumor metastasis. Reviewing the available literature, it has been hypothesized that the following factors play a role in the pathophysiology of this phenomenon: progesterone and estrogen receptors, cell-to-cell adhesion molecules, rich vascularization, favorable metabolic, micro-and immunological environment. Meningiomas seem to be the most common type of intracranial neoplasm to host a metastasis. There is a difference between tumor-to-tumor metastasis and collision tumors. The former implies a recipient role of the host tumor, and the latter refers to a co-localization of two different tumors that grow into one another, both being in the same organ. Tumor-to-tumor brain metastasis is a well-described phenomenon but with unclear pathophysiology. Deeper knowledge could be beneficial for its management.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Bräutigam, Konstantin

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0967-5868

Publisher:

Elsevier

Language:

English

Submitter:

Dr. Konstantin Bräutigam

Date Deposited:

12 Aug 2022 11:36

Last Modified:

12 Aug 2022 11:46

Publisher DOI:

10.1016/j.jocn.2021.08.028

PubMed ID:

34656242

Uncontrolled Keywords:

Collision tumor Meningioma metastasis Nested tumor Tumor inside tumor Tumor-to-meningioma Tumor-to-tumor

BORIS DOI:

10.48350/171838

URI:

https://boris.unibe.ch/id/eprint/171838

Actions (login required)

Edit item Edit item
Provide Feedback