Use of statins after liver transplantation is associated with improved survival: results of a nationwide study.

Becchetti, Chiara; Dirchwolf, Melisa; Schropp, Jonas; Magini, Giulia; Müllhaupt, Beat; Immer, Franz; Dufour, Jean-François; Banz, Vanessa; Berzigotti, Annalisa; Bosch, Jaime (2022). Use of statins after liver transplantation is associated with improved survival: results of a nationwide study. Alimentary pharmacology & therapeutics, 56(7), pp. 1194-1204. Wiley-Blackwell 10.1111/apt.17192

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BACKGROUND

There is limited information on the effects of statins on the outcomes of liver transplantation (LT), regarding either their use by LT recipients or donors.

AIM

To analyse the association between statin exposure and recipient and graft survival.

METHODS

We included adult LT recipients with deceased donors in a nationwide prospective database study. Using a multistate modelling approach, we examined the effect of statins on the transition hazard between LT, biliary and vascular complications and death, allowing for recurring events. The observation time was 3 years.

RESULTS

We included 998 (696 male, 70%, mean age 54.46 ± 11.14 years) LT recipients. 14% of donors and 19% of recipients were exposed to statins during the study period. During follow-up, 141 patients died; there were 40 re-LT and 363 complications, with 66 patients having two or more complications. Treatment with statins in the recipient was modelled as a concurrent covariate and associated with lower mortality after LT (HR = 0.35; 95% CI 0.12-0.98; p = 0.047), as well as a significant reduction of re-LT (p = 0.004). However, it was not associated with lower incidence of complications (HR = 1.25; 95% CI = 0.85-1.83; p = 0.266). Moreover, in patients developing complications, statin use was significantly associated with decreased mortality (HR = 0.10; 95% CI = 0.01-0.81; p = 0.030), and reduced recurrence of complications (HR = 0.43; 95% CI = 0.20-0.93; p = 0.032).

CONCLUSIONS

Statin use by LT recipients may confer a survival advantage. Statin administration should be encouraged in LT recipients when clinically indicated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Becchetti, Chiara, Dufour, Jean-François, Banz Wüthrich, Vanessa, Berzigotti, Annalisa, Bosch Genover, Jaime

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0269-2813

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Pubmed Import

Date Deposited:

19 Aug 2022 10:56

Last Modified:

05 Dec 2022 16:22

Publisher DOI:

10.1111/apt.17192

PubMed ID:

35979872

Uncontrolled Keywords:

cardiovascular disease dyslipidemia solid organ transplantation survival

BORIS DOI:

10.48350/172200

URI:

https://boris.unibe.ch/id/eprint/172200

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