Pharmacological Induction of Granulocyte Cell Death As Therapeutic Strategy.

Kaufmann, Thomas; Simon, Hans-Uwe (2023). Pharmacological Induction of Granulocyte Cell Death As Therapeutic Strategy. Annual review of pharmacology and toxicology, 63, pp. 231-247. Annual Reviews Inc. 10.1146/annurev-pharmtox-051921-115130

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Apoptosis is central for the maintenance of health. In the immune system, apoptosis guarantees proper development of immune cells and shutdown of immune reactions by the coordinated elimination of activated immune cells. Limitation of the life span of granulocytes is important, as overactivation of these cells is associated with chronic inflammation and collateral tissue damage. Consequently, targeted induction of granulocyte apoptosis may be beneficial in the course of respective immune disorders. Anti-inflammatory drugs such as glucocorticoids and monoclonal antibodies against IL-5Rα exert their function in part by triggering eosinophil apoptosis. Agonistic antibodies targeting Siglec-8 or death receptors are tested (pre)clinically. Moreover, a new class of inhibitors targeting antiapoptotic BCL-2 proteins shows great promise for anticancer treatments. Because of their specificity and tolerable side effects, these so-called BH3 mimetics may be worthwhile to evaluate in inflammatory disorders. Here, we review past and recent data on pharmacological apoptosis induction of granulocytes and highlight respective therapeutic potential. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 63 is January 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Item Type:

Journal Article (Review Article)

Division/Institute:

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04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Kaufmann, Thomas (B), Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0362-1642

Publisher:

Annual Reviews Inc.

Language:

English

Submitter:

Pubmed Import

Date Deposited:

29 Aug 2022 13:24

Last Modified:

30 May 2024 15:05

Publisher DOI:

10.1146/annurev-pharmtox-051921-115130

PubMed ID:

36028226

BORIS DOI:

10.48350/172398

URI:

https://boris.unibe.ch/id/eprint/172398

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