Regression of Graft Steatosis After Liver Transplantation.

Meyer, Helene; Maurer, Martin H; Staufer, Katharina; Berzigotti, Annalisa; Banz, Vanessa (2022). Regression of Graft Steatosis After Liver Transplantation. Progress in transplantation, 32(4), pp. 321-326. Sage 10.1177/15269248221122868

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Introduction: Liver grafts with limited steatosis are currently used for liver transplantation, but the natural history of graft steatosis is not well known. Project Aims or Questions: This program evaluation aimed at assessing changes of steatosis after liver transplantation. Design: A retrospective chart review was performed assessing presence and severity of steatosis in the liver explant and in time zero donor graft biopsies carried out at the time-point of liver transplantation on histopathology and on imaging one year thereafter in 30 well characterized patients. Results: Ten patients (33%) showed steatosis on explant. Time zero biopsy revealed steatosis in 18 grafts (60%) and no steatosis in 12 (40%). One year after transplantation, 8 patients (27%) had steatosis and 22 patients (63%) had none. Fourteen patients (47%) showed changes in steatosis: 12 showed resolution and 2 showed de novo steatosis. Explant macrovesicular steatosis was associated with presence of steatosis 1 year after transplantation (binary logistic regression model, p = 0.014), but not macrovesicular steatosis in the donor graft at time-point of transplantation. Conclusion: Resolution of graft steatosis was frequent. Presence of steatosis in the recipient's liver, but not graft steatosis, was a risk factor for steatosis 1 year after transplantation. Factors related to the recipient seem to prevail over donor-related factors in determining the persistence or de novo appearance of steatosis after liver transplantation.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
UniBE Contributor:	Maurer, Martin, Berzigotti, Annalisa, Banz Wüthrich, Vanessa
Subjects:	600 Technology > 610 Medicine & health
ISSN:	2164-6708
Publisher:	Sage
Language:	English
Submitter:	Pubmed Import
Date Deposited:	02 Sep 2022 16:06
Last Modified:	05 Dec 2022 16:23
Publisher DOI:	10.1177/15269248221122868
PubMed ID:	36047000
Uncontrolled Keywords:	NASH cirrhosis fat content fibrosis ultrasound
URI:	https://boris.unibe.ch/id/eprint/172629