Expression of the protease gene HF as a marker in rejecting allogeneic murine heart transplants.

Mueller, Christoph; Shelby, Jane; Weissman, Irwing L; Périnat-Frey, Therese; Eichwald, Ernst J (1991). Expression of the protease gene HF as a marker in rejecting allogeneic murine heart transplants. Transplantation, 51(2), pp. 514-517. Lippincott Williams & Wilkins 10.1097/00007890-199102000-00046

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Phenotypic characterization of the inflammatory infiltrate often provides very little information about the fate of a transplant. Therefore we decided to look for functional markers, characteristic for activated effector cells involved in the rejection of primarily vascularized MHC-mismatched heart transplants in mice. Infiltrating cells in the interstitium of eventually rejected allogeneic heart transplants were found to express the gene for the serine esterase HF (granzyme A) in high numbers already on day 2 following transplantation, whereas HF mRNA positive cells were absent, or only rarely found, in syngeneic nonrejecting transplants throughout the entire observation period of 10 days after transplantation. These findings could also become of importance for the prediction of the outcome of organ transplants in humans.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Müller, Christoph

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0041-1337

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Christoph Müller

Date Deposited:

21 Sep 2022 12:42

Last Modified:

21 Sep 2022 12:52

Publisher DOI:

10.1097/00007890-199102000-00046

PubMed ID:

1994548

BORIS DOI:

10.48350/172931

URI:

https://boris.unibe.ch/id/eprint/172931

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