Altermatt, Hans Jörg; Gebbers, Jan-Olaf; Müller, Christoph; Laissue, Jean; Arnold, Wofgang (1992). Immunohistochemical characterization of the human endolymphatic sac and its associated cell populations. Acta oto-laryngologica, 112(2), pp. 299-305. Taylor & Francis 10.1080/00016489.1992.11665422
Full text not available from this repository.The use of monoclonal and polyclonal antibodies as specific markers for the localization of tissue constituents in situ allows the characterization of cells according to their state of differentiation and the detection of cellular antigens related to the function of cells and tissues. Our studies focus on the immunohistochemical characterization of the human endolymphatic sac (ES) and its associated cell populations. A panel of 37 monoclonal and polyclonal antibodies were used on frozen sections and fixed material from 64 ES of 32 persons without any clinically known inner ear disorders. The ES were removed at the time of autopsy; case histories were available. The results of our studies on the extraosseous part of the human ES support the assumption that the epithelium is metabolically active and capable of both secretion and absorption. The reactivity of the epithelial cells with antibodies against neuron specific enolase, chromogranin and somatostatin, respectively, implies a paracrine activity of the ES. Further results obtained with antibodies specific for cells of the immune system indicate a possible role of the human ES in the inner ear immune defence and a functional relationship of the ES to the common mucosa-associated immune system.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Müller, Christoph (C), Laissue, Jean |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0001-6489 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Christoph Müller |
Date Deposited: |
23 Sep 2022 09:37 |
Last Modified: |
29 Mar 2023 23:38 |
Publisher DOI: |
10.1080/00016489.1992.11665422 |
PubMed ID: |
1604996 |
URI: |
https://boris.unibe.ch/id/eprint/172939 |
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