Hunger, Robert E; Hristic, Mirjana; Mueller, Christoph; Kappeler, Andreas; Altermatt, Hans Jörg (1997). Detection of perforin and tumour necrosis factor alpha mRNA expressing cells in sclerosing lymphocytic lobulitis of the breast. Journal of clinical pathology, 50(4), pp. 310-313. BMJ Publishing Group 10.1136/jcp.50.4.310
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The contribution of a cellular immune response to tissue destruction in sclerosing lymphocytic lobulitis of the breast is not well understood. In this study, comparison of one case with two age matched control cases showed an increased frequency of activated perforin mRNA expressing cells at the site of tissue destruction in lobulitis. Along with the detection of tumour necrosis factor alpha (TNF alpha) mRNA expressing cells in the infiltrates, the striking association of perforin expressing activated cytotoxic cells with remaining gland parenchyma and the high level of perforin mRNA suggests activation of cytotoxic cells in situ. These findings are evidence that cell mediated cytotoxicity plays a significant role in the destruction of mammary gland tissue in sclerosing lymphocytic lobulitis.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Müller, Christoph (C) |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0021-9746 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Christoph Müller |
Date Deposited: |
23 Sep 2022 09:19 |
Last Modified: |
29 Mar 2023 23:38 |
Publisher DOI: |
10.1136/jcp.50.4.310 |
PubMed ID: |
9215147 |
BORIS DOI: |
10.48350/172960 |
URI: |
https://boris.unibe.ch/id/eprint/172960 |
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