Mouse Model of Subarachnoid Hemorrhage: Technical Note on the Filament Perforation Model

Muroi, Carl; Fujioka, Masayuki; Marbacher, Serge; Fandino, Javier; Keller, Emanuela; Iwasaki, Katsunori; Mishima, Kenichi (2014). Mouse Model of Subarachnoid Hemorrhage: Technical Note on the Filament Perforation Model. In: Fandino, Javier; Marbacher, Serge; Fathi, Ali-Reza; Muroi, Carl; Keller, Emanuela (eds.) Neurovascular Events After Subarachnoid Hemorrhage. Acta Neurochirurgica Supplement: Vol. 120 (pp. 315-320). Cham: Springer 10.1007/978-3-319-04981-6_54

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Experiments using genetically engineered mice are regarded as indispensable to gaining a better understanding of the molecular pathophysiology in neuronal injury after subarachnoid hemorrhage (SAH). Therefore, mouse SAH models are becoming increasingly important. The circle of Willis perforation (cWp) model is the most frequently used mouse SAH model. We report and discuss the technical surgical approach, results, and difficulties associated with the cWp model, with reference to the existing literature. Our results largely confirmed previously published results. This model may be the first choice at present, because important pathologies can be reproduced in this model and most findings in the literature are based on it.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie

UniBE Contributor:

Marbacher, Serge and Fandino, Javier

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0065-1419

ISBN:

978-3-319-04980-9

Series:

Acta Neurochirurgica Supplement

Publisher:

Springer

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

16 Sep 2022 11:57

Last Modified:

05 Dec 2022 16:24

Publisher DOI:

10.1007/978-3-319-04981-6_54

BORIS DOI:

10.48350/172999

URI:

https://boris.unibe.ch/id/eprint/172999

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