Assessing the efficiency of a pharmacokinetic-based algorithm for target-controlled infusion of ketamine in ponies

Levionnois, O L; Mevissen, M; Thormann, W; Spadavecchia, C (2010). Assessing the efficiency of a pharmacokinetic-based algorithm for target-controlled infusion of ketamine in ponies. Research in veterinary science, 88(3), pp. 512-8. London: Association for Veterinary Teaching and Research Work 10.1016/j.rvsc.2009.12.004

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The objective of this study was to assess a pharmacokinetic algorithm to predict ketamine plasma concentration and drive a target-controlled infusion (TCI) in ponies. Firstly, the algorithm was used to simulate the course of ketamine enantiomers plasma concentrations after the administration of an intravenous bolus in six ponies based on individual pharmacokinetic parameters obtained from a previous experiment. Using the same pharmacokinetic parameters, a TCI of S-ketamine was then performed over 120 min to maintain a concentration of 1 microg/mL in plasma. The actual plasma concentrations of S-ketamine were measured from arterial samples using capillary electrophoresis. The performance of the simulation for the administration of a single bolus was very good. During the TCI, the S-ketamine plasma concentrations were maintained within the limit of acceptance (wobble and divergence <20%) at a median of 79% (IQR, 71-90) of the peak concentration reached after the initial bolus. However, in three ponies the steady concentrations were significantly higher than targeted. It is hypothesized that an inaccurate estimation of the volume of the central compartment is partly responsible for that difference. The algorithm allowed good predictions for the single bolus administration and an appropriate maintenance of constant plasma concentrations.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Pharmacology and Toxicology
04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research (discontinued)

UniBE Contributor:

Levionnois, Olivier; Mevissen, Meike; Thormann, Wolfgang and Spadavecchia, Claudia

ISSN:

0034-5288

Publisher:

Association for Veterinary Teaching and Research Work

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

04 May 2014 23:05

Publisher DOI:

10.1016/j.rvsc.2009.12.004

PubMed ID:

20053414

Web of Science ID:

000278177300029

URI:

https://boris.unibe.ch/id/eprint/1730 (FactScience: 203670)

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