Young, Bernadette C; Bush, Stephen J; Lipworth, Sam; George, Sophie; Dingle, Kate E; Sanderson, Nick; Brankin, Alice; Walker, Timothy; Sharma, Srilakshmi; Leong, James; Plaha, Puneet; Hofer, Monika; Chiodini, Peter; Gottstein, Bruno; Furrer, Lavinia; Crook, Derrick; Brent, Andrew (2022). Modern Solutions for Ancient Pathogens: Direct Pathogen Sequencing for Diagnosis of Lepromatous Leprosy and Cerebral Coenurosis. Open Forum Infectious Diseases, 9(9), ofac428. Oxford University Press 10.1093/ofid/ofac428
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Microbes unculturable in vitro remain diagnostically challenging, dependent historically on clinical findings, histology, or targeted molecular detection. We applied whole-genome sequencing directly from tissue to diagnose infections with mycobacteria (leprosy) and parasites (coenurosis). Direct pathogen DNA sequencing provides flexible solutions to diagnosis of difficult pathogens in diverse contexts.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Gottstein, Bruno |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2328-8957 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Sep 2022 09:01 |
Last Modified: |
05 Dec 2022 16:24 |
Publisher DOI: |
10.1093/ofid/ofac428 |
PubMed ID: |
36119959 |
Uncontrolled Keywords: |
Taenia coenurosis leprosy mycobacteria whole genome sequencing |
BORIS DOI: |
10.48350/173089 |
URI: |
https://boris.unibe.ch/id/eprint/173089 |
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