Kwong Chung, Cheong Kc; Brasseit, Jennifer; Althaus-Steiner, Esther; Rihs, Silvia; Mueller, Christoph (2017). Mouse Model of Reversible Intestinal Inflammation. Bio-protocol, 7(6), e2173. 10.21769/BioProtoc.2173
Full text not available from this repository.Current therapies to treat inflammatory bowel disease by dampening excessive inflammatory immune responses have had limited success ( Reinisch et al., 2011 ; Rutgeerts et al., 2005 ; Sandborn et al., 2012 ). To develop new therapeutic interventions, there is a need for better understanding of the mechanisms that are operative during mucosal healing (Pineton de Chambrun et al., 2010 ). To this end, a reversible model of colitis was developed in which colitis induced by adoptive transfer of naïve CD4+ CD45RBhi T cells in lymphopenic mice can be reversed through depletion of colitogenic CD4+ T cells ( Brasseit et al., 2016 ).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Müller, Christoph (C) |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2331-8325 |
Language: |
English |
Submitter: |
Christoph Müller |
Date Deposited: |
23 Sep 2022 10:08 |
Last Modified: |
29 Mar 2023 23:38 |
Publisher DOI: |
10.21769/BioProtoc.2173 |
PubMed ID: |
34458484 |
Uncontrolled Keywords: |
Colitis Mucosal healing Relapsing disease Remission |
URI: |
https://boris.unibe.ch/id/eprint/173183 |
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