de Wit, Yasmin E S; Hamzeh-Cognasse, Hind; Cognasse, Fabrice; Ten Brinke, Anja; Zeerleder, Sacha S (2022). DAMPS and complement activation in platelet concentrates that induce adverse reactions in patients. Transfusion, 62(9), pp. 1721-1726. Wiley-Blackwell 10.1111/trf.17061
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BACKGROUND
Patients with severe thrombocytopenia due to bone marrow failure and after chemotherapy are still treated with platelet transfusions. Platelet concentrates (PC) are associated with a high incidence of adverse reactions (AR). Platelet-derived damage-associated molecular patterns (DAMPS) and complement were proposed to play a role in the pathology of AR.
STUDY DESIGN AND METHODS
Single donor apheresis platelet concentrates (SDA PCs) were produced in a regional setting of the French Blood Establishment. After transfusion samples were collected from PC and possible AR in patients were recorded. Platelet activation markers, High mobility group box 1 (HMGB1) and complement activation products (CAP) were measured. The correlation between platelet activation, and HMGB1 and complement activation was analyzed.
RESULTS
A total of 56 PC were included in the study. 30 PC induced no AR, and 26 induced AR (Febrile non-hemolytic transfusion reaction n = 16; Atypical Allergic Transfusion Reactions n = 11; hemodynamic instability n = 5) in the patients. The levels of P-selectin, sCD40L, HMGB1, C3b/c, and C4b/c were all significantly increased in PC that induced AR following transfusion in patients. Additionally, HMGB1, C3b/c, and C4b/c were positively correlated with P-selectin and sCD40L.
CONCLUSION
In this study, we observed an association between HMGB1 and CAP and the incidence of AR. Furthermore, we demonstrated that both HMGB1 and complement activation were correlated to platelet activation.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory |
UniBE Contributor: |
Zeerleder, Sacha Sergio |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0041-1132 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Pierrette Durand Lüthi |
Date Deposited: |
07 Oct 2022 14:06 |
Last Modified: |
05 Dec 2022 16:26 |
Publisher DOI: |
10.1111/trf.17061 |
PubMed ID: |
35950480 |
Uncontrolled Keywords: |
DAMPS HMGB1 complement activation febrile non-hemolytic reaction platelet concentrates transfusion transfusion adverse reactions |
BORIS DOI: |
10.48350/173565 |
URI: |
https://boris.unibe.ch/id/eprint/173565 |
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