Papageorgiou, Maria; Biver, Emmanuel; Mareschal, Julie; Phillips, Nicholas Edward; Hemmer, Alexandra; Biolley, Emma; Schwab, Nathalie; Manoogian, Emily N C; Gonzalez Rodriguez, Elena; Aeberli, Daniel; Hans, Didier; Pot, Caroline; Panda, Satchidananda; Rodondi, Nicolas; Ferrari, Serge L; Collet, Tinh-Hai (2023). The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial. Obesity, 31 Suppl 1(Suppl 1), pp. 85-95. Wiley 10.1002/oby.23577
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Papageorgiou_ObesitySilverSpring_2023.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (2MB) | Preview |
OBJECTIVE
This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health.
METHODS
Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response.
RESULTS
In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes.
CONCLUSIONS
TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.
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