Thériault, Sébastien; Imboden, Medea; Biggs, Mary L; Austin, Thomas R; Aeschbacher, Stefanie; Schaffner, Emmanuel; Brody, Jennifer A; Bartz, Traci M; Risch, Martin; Grossmann, Kirsten; Lin, Henry J; Soliman, Elsayed Z; Post, Wendy S; Risch, Lorenz; Krieger, Jose E; Pereira, Alexandre C; Heckbert, Susan R; Sotoodehnia, Nona; Probst-Hensch, Nicole M and Conen, David (2022). Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency. iScience, 25(10), p. 105210. Elsevier 10.1016/j.isci.2022.105210
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Premature atrial contractions (PACs) are frequently observed on electrocardiograms and are associated with increased risks of atrial fibrillation (AF), stroke, and mortality. In this study, we aimed to identify genetic susceptibility loci for PAC frequency. We performed a genome-wide association study meta-analysis with PAC frequency obtained from ambulatory cardiac monitoring in 4,831 individuals of European ancestry. We identified a genome-wide significant locus at the SCN5A gene. The lead variant, rs7373862, located in an intron of SCN5A, was associated with an increase of 0.12 [95% CI 0.08-0.16] standard deviations of the normalized PAC frequency per risk allele. Among genetic variants previously associated with AF, there was a significant enrichment in concordance of effect for PAC frequency (n = 73/106, p = 5.1 × 10-5). However, several AF risk loci, including PITX2, were not associated with PAC frequency. These findings suggest the existence of both shared and distinct genetic mechanisms for PAC frequency and AF.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry |
UniBE Contributor: |
Risch, Lorenz |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2589-0042 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
24 Oct 2022 13:27 |
Last Modified: |
05 Dec 2022 16:26 |
Publisher DOI: |
10.1016/j.isci.2022.105210 |
PubMed ID: |
36267918 |
Uncontrolled Keywords: |
Cardiovascular medicine Clinical genetics Genomics Human genetics |
BORIS DOI: |
10.48350/174002 |
URI: |
https://boris.unibe.ch/id/eprint/174002 |
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