Response of gram-positive bacteria to copper stress

Solioz, Marc; Abicht, Helge K; Mermod, Mélanie; Mancini, Stefano (2010). Response of gram-positive bacteria to copper stress. Journal of biological and inorganic chemistry JBIC, 15(1), pp. 3-14. Berlin: Springer-Verlag 10.1007/s00775-009-0588-3

[img]
Preview
Text
775_2009_Article_588.pdf - Published Version
Available under License Publisher holds Copyright.

Download (968kB) | Preview

The Gram-positive bacteria Enterococcus hirae, Lactococcus lactis, and Bacillus subtilis have received wide attention in the study of copper homeostasis. Consequently, copper extrusion by ATPases, gene regulation by copper, and intracellular copper chaperoning are understood in some detail. This has provided profound insight into basic principles of how organisms handle copper. It also emerged that many bacterial species may not require copper for life, making copper homeostatic systems pure defense mechanisms. Structural work on copper homeostatic proteins has given insight into copper coordination and bonding and has started to give molecular insight into copper handling in biological systems. Finally, recent biochemical work has shed new light on the mechanism of copper toxicity, which may not primarily be mediated by reactive oxygen radicals.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Solioz, Marc

ISSN:

0949-8257

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

30 Jul 2020 08:52

Publisher DOI:

10.1007/s00775-009-0588-3

PubMed ID:

19774401

Web of Science ID:

000272174400002

BORIS DOI:

10.7892/boris.1743

URI:

https://boris.unibe.ch/id/eprint/1743 (FactScience: 203683)

Actions (login required)

Edit item Edit item
Provide Feedback