Sunguc, Ceren; Hawkins, Michael M; Winter, David L; Dudley, Isabelle M; Heymer, Emma J; Teepen, Jop C; Allodji, Rodrigue S; Belle, Fabiën N; Bagnasco, Francesca; Byrne, Julianne; Bárdi, Edit; Ronckers, Cécile M; Haddy, Nadia; Gudmundsdottir, Thorgerdur; Garwicz, Stanislaw; Jankovic, Momcilo; van der Pal, Helena J H; Mazić, Maja Česen; Schindera, Christina; Grabow, Desiree; ... (2023). Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study. British journal of cancer, 128(1), pp. 80-90. Nature Publishing Group 10.1038/s41416-022-02016-w
|
Text
Sunguc_BrJCancer_2023.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (851kB) | Preview |
BACKGROUND
Survivors of childhood cancer are at risk of subsequent primary malignant neoplasms (SPNs), but the risk for rarer types of SPNs, such as oral cancer, is uncertain. Previous studies included few oral SPNs, hence large-scale cohorts are required to identify groups at risks.
METHODS
The PanCareSurFup cohort includes 69,460 5-year survivors of childhood cancer across Europe. Risks of oral SPNs were defined by standardised incidence ratios (SIRs), absolute excess risks and cumulative incidence.
RESULTS
One hundred and forty-five oral SPNs (64 salivary gland, 38 tongue, 20 pharynx, 2 lip, and 21 other) were ascertained among 143 survivors. Survivors were at 5-fold risk of an oral SPN (95% CI: 4.4-5.6). Survivors of leukaemia were at greatest risk (SIR = 19.2; 95% CI: 14.6-25.2) followed by bone sarcoma (SIR = 6.4, 95% CI: 3.7-11.0), Hodgkin lymphoma (SIR = 6.2, 95% CI: 3.9-9.9) and soft-tissue sarcoma (SIR = 5.0, 95% CI: 3.0-8.5). Survivors treated with radiotherapy were at 33-fold risk of salivary gland SPNs (95% CI: 25.3-44.5), particularly Hodgkin lymphoma (SIR = 66.2, 95% CI: 43.6-100.5) and leukaemia (SIR = 50.5, 95% CI: 36.1-70.7) survivors. Survivors treated with chemotherapy had a substantially increased risk of a tongue SPN (SIR = 15.9, 95% CI: 10.6-23.7).
CONCLUSIONS
Previous radiotherapy increases the risk of salivary gland SPNs considerably, while chemotherapy increases the risk of tongue SPNs substantially. Awareness of these risks among both health-care professionals and survivors could play a crucial role in detecting oral SPNs early.
Actions (login required)
 |
Edit item |