The GPVI - Fc Fusion Protein Revacept Reduces Thrombus Formation and Improves Vascular Dysfunction in Atherosclerosis without Any Impact on Bleeding Times

Ungerer, Martin; Li, Zhongmin; Baumgartner, Christine; Goebel, Silvia; Vogelmann, Jasmin; Holthoff, Hans-Peter; Gawaz, Meinrad; Münch, Götz (2013). The GPVI - Fc Fusion Protein Revacept Reduces Thrombus Formation and Improves Vascular Dysfunction in Atherosclerosis without Any Impact on Bleeding Times. PLoS ONE, 8(8), e71193. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0071193

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Glycoprotein VI (GPVI) is a key platelet receptor which mediates plaque-induced platelet activation and consecutive atherothrombosis, but GPVI is also involved in platelet-mediated atheroprogression. Therefore, interference in GPVI-mediated platelet activation has the potential to combine short-term and long-term beneficial effects, specificity and safety especially regarding bleeding complications.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Baumgartner, Christine

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:42

Last Modified:

13 Dec 2014 06:45

Publisher DOI:

10.1371/journal.pone.0071193

PubMed ID:

23951109

Web of Science ID:

000308012403215

BORIS DOI:

10.7892/boris.17470

URI:

https://boris.unibe.ch/id/eprint/17470 (FactScience: 225250)

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