Ungerer, Martin; Li, Zhongmin; Baumgartner, Christine; Goebel, Silvia; Vogelmann, Jasmin; Holthoff, Hans-Peter; Gawaz, Meinrad; Münch, Götz (2013). The GPVI - Fc Fusion Protein Revacept Reduces Thrombus Formation and Improves Vascular Dysfunction in Atherosclerosis without Any Impact on Bleeding Times. PLoS ONE, 8(8), e71193. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0071193
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Glycoprotein VI (GPVI) is a key platelet receptor which mediates plaque-induced platelet activation and consecutive atherothrombosis, but GPVI is also involved in platelet-mediated atheroprogression. Therefore, interference in GPVI-mediated platelet activation has the potential to combine short-term and long-term beneficial effects, specificity and safety especially regarding bleeding complications.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Baumgartner, Christine |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:42 |
Last Modified: |
05 Dec 2022 14:13 |
Publisher DOI: |
10.1371/journal.pone.0071193 |
PubMed ID: |
23951109 |
Web of Science ID: |
000308012403215 |
BORIS DOI: |
10.7892/boris.17470 |
URI: |
https://boris.unibe.ch/id/eprint/17470 (FactScience: 225250) |
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