Felli, Emanuele; Cinelli, Lorenzo; Bannone, Elisa; Giannone, Fabio; Muttillo, Edoardo Maria; Barberio, Manuel; Keller, Deborah Susan; Rodríguez-Luna, María Rita; Okamoto, Nariaki; Collins, Toby; Hostettler, Alexandre; Schuster, Catherine; Mutter, Didier; Pessaux, Patrick; Marescaux, Jacques; Gioux, Sylvain; Felli, Eric; Diana, Michele (2022). Hyperspectral Imaging in Major Hepatectomies: Preliminary Results from the Ex-Machyna Trial. Cancers, 14(22) MDPI AG 10.3390/cancers14225591
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Ischemia-reperfusion injury during major hepatic resections is associated with high rates of post-operative complications and liver failure. Real-time intra-operative detection of liver dysfunction could provide great insight into clinical outcomes. In the present study, we demonstrate the intra-operative application of a novel optical technology, hyperspectral imaging (HSI), to predict short-term post-operative outcomes after major hepatectomy. We considered fifteen consecutive patients undergoing major hepatic resection for malignant liver lesions from January 2020 to June 2021. HSI measures included tissue water index (TWI), organ hemoglobin index (OHI), tissue oxygenation (StO2%), and near infrared (NIR). Pre-operative, intra-operative, and post-operative serum and clinical outcomes were collected. NIR values were higher in unhealthy liver tissue (p = 0.003). StO2% negatively correlated with post-operative serum ALT values (r = -0.602), while ΔStO2% positively correlated with ALP (r = 0.594). TWI significantly correlated with post-operative reintervention and OHI with post-operative sepsis and liver failure. In conclusion, the HSI imaging system is accurate and precise in translating from pre-clinical to human studies in this first clinical trial. HSI indices are related to serum and outcome metrics. Further experimental and clinical studies are necessary to determine clinical value of this technology.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology |
UniBE Contributor: |
Felli, Eric |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Nov 2022 12:38 |
Last Modified: |
05 Dec 2022 16:29 |
Publisher DOI: |
10.3390/cancers14225591 |
PubMed ID: |
36428685 |
Uncontrolled Keywords: |
hepatectomy hyperspectral imaging image-guided surgery major hepatectomy post-hepatectomy liver failure (PHLF) |
BORIS DOI: |
10.48350/175195 |
URI: |
https://boris.unibe.ch/id/eprint/175195 |
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