Fully closed-loop insulin delivery in patients undergoing pancreatic surgery.

Krutkyte, Gabija; Roos, Jonathan; Schuerch, Daniel; Czerlau, Cecilia; Wilinska, Malgorzata; Wüthrich, Patrick; Herzig, David; Hovorka, Roman; Vogt, Andreas; Gloor, Beat; Bally, Lia (2023). Fully closed-loop insulin delivery in patients undergoing pancreatic surgery. Diabetes technology & therapeutics, 25(3), pp. 206-211. Mary Ann Liebert 10.1089/dia.2022.0400

[img] Text
dia.2022.0400.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.
Download (749kB)

The central role of pancreas in glucose regulation imposes high demands on perioperative glucose management in patients undergoing pancreatic surgery. In a post-hoc subgroup analysis of a randomized controlled trial, we evaluated the perioperative use of subcutaneous (SC) fully closed-loop (FCL, CamAPS HX) versus usual care (UC) insulin therapy in patients undergoing partial or total pancreatic resection. Glucose control was compared using continuous glucose monitoring (CGM) metrics (% time with CGM values between 5.6 and 10.0mmol/L and more). Over the time of hospitalisation, FCL resulted in better glucose control than UC with more time spent in the target range 5.6-10.0mmol/L (mean (SD) % time in target 77.7±4.6 % and 41.1±19.5 % in FCL vs. UC subjects, respectively; mean difference 36.6 % (95% CI [18.5; 54.8])), without increasing the risk of hypoglycaemia. Findings suggest that an adaptive SC FCL approach effectively accommodated the highly variable insulin needs in patients undergoing pancreatic surgery.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy > Partial clinic Insel
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy

Graduate School:

 Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

 Krutkyte, Gabija, Czerlau, Cecilia, Wüthrich, Patrick Yves, Herzig, David, Vogt, Andreas, Gloor, Beat, Bally, Lia Claudia

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1520-9156

Publisher:

 Mary Ann Liebert

Language:

 English

Submitter:

 Pubmed Import

Date Deposited:

 01 Dec 2022 10:44

Last Modified:

 06 Apr 2023 09:07

Publisher DOI:

 10.1089/dia.2022.0400

PubMed ID:

 36449375

BORIS DOI:

 10.48350/175369

URI:

 https://boris.unibe.ch/id/eprint/175369

Actions (login required)

Edit item Edit item
Provide Feedback