Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines.

Fernandes, Queenie; Inchakalody, Varghese Philipose; Merhi, Maysaloun; Mestiri, Sarra; Taib, Nassiba; Moustafa Abo El-Ella, Dina; Bedhiafi, Takwa; Raza, Afsheen; Al-Zaidan, Lobna; Mohsen, Mona O; Yousuf Al-Nesf, Mariam Ali; Hssain, Ali Ait; Yassine, Hadi Mohamad; Bachmann, Martin F; Uddin, Shahab; Dermime, Said (2022). Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines. Annals of medicine, 54(1), pp. 524-540. Taylor & Francis 10.1080/07853890.2022.2031274

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The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing rapid and sensitive diagnostic technologies is now more challenging due to emerging variants and varying symptoms exhibited among the infected individuals. In addition to this, vaccines remain the major mainstay of prevention and protection against infection. Novel vaccines and drugs are constantly being developed to unleash an immune response for the robust targeting of SARS-CoV-2 and its associated variants. In this review, we provide an updated perspective on the current challenges posed by the emergence of novel SARS-CoV-2 mutants/variants and the evolution of diagnostic techniques to enable their detection. In addition, we also discuss the development, formulation, working mechanisms, advantages, and drawbacks of some of the most used vaccines/therapeutic drugs and their subsequent immunological impact.Key messageThe emergence of novel variants of the SARS-CoV-2 in the past couple of months, highlights one of the primary challenges in the diagnostics, treatment, as well as vaccine development against the virus.Advancements in SARS-CoV-2 detection include nucleic acid based, antigen and immuno- assay-based and antibody-based detection methodologies for efficient, robust, and quick testing; while advancements in COVID-19 preventive and therapeutic strategies include novel antiviral and immunomodulatory drugs and SARS-CoV-2 targeted vaccines.The varied COVID-19 vaccine platforms and the immune responses induced by each one of them as well as their ability to battle post-vaccination infections have all been discussed in this review.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Rheumatologie

UniBE Contributor:

Mohsen, Mona Omar Mahmoud, Bachmann, Martin (B)

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1365-2060

Publisher:

Taylor & Francis

Language:

English

Submitter:

Lee-Anne Brand

Date Deposited:

21 Dec 2022 10:06

Last Modified:

29 Mar 2023 23:38

Publisher DOI:

10.1080/07853890.2022.2031274

PubMed ID:

35132910

Uncontrolled Keywords:

COVID-19 Coronaviruses Omicron SARS-CoV-2 Viral epidemic diagnostic testing immunological responses vaccine

BORIS DOI:

10.48350/176178

URI:

https://boris.unibe.ch/id/eprint/176178

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