Evaluating the Impact of Applying Personal Glucose Targets in a Closed-Loop System for People With Type 1 Diabetes.

Fattah, Mustafa; Boughton, Charlotte K; Ware, Julia; Allen, Janet M; Hartnell, Sara; Willinska, Malgorzata E; Thankamony, Ajay; de Beaufort, Carine; Campbell, Fiona M; Fröhlich-Reiterer, Elke; Hofer, Sabine E; Kapellen, Thomas M; Rami-Merhar, Birgit; Ghatak, Atrayee; Randell, Tabitha L; Besser, Rachel E J; Elleri, Daniela; Trevelyan, Nicola; Denvir Md, Louise; Davis, Nikki; ... (2022). Evaluating the Impact of Applying Personal Glucose Targets in a Closed-Loop System for People With Type 1 Diabetes. (In Press). Journal of diabetes science and technology(19322968221145184), p. 19322968221145184. Diabetes Technology Society 10.1177/19322968221145184

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BACKGROUND

CamAPS FX is a hybrid closed-loop smartphone app used to manage type one diabetes. The closed-loop algorithm has a default target glucose of 5.8 mmol/L (104.5 mg/dL), but users can select personal glucose targets (adjustable between 4.4 mmol/L and 11.0 mmol/L [79 mg/dL and 198 mg/dL, respectively]).

METHOD

In this post-hoc analysis, we evaluated the impact of personal glucose targets on glycemic control using data from participants in five randomized controlled trials.

RESULTS

Personal glucose targets were widely used, with 20.3% of all days in the data set having a target outside the default target bin (5.5-6.0 mmol/L [99-108 mg/dL]). Personal glucose targets >6.5 mmol/L (117 mg/dL) were associated with significantly less time in target range (3.9-10.0 mmol/L [70-180 mg/dL]; 6.5-7.0 mmol/L [117-126 mg/dL]: mean difference = -3.2 percentage points [95% CI: -5.3 to -1.2; P < .001]; 7.0-7.5 mmol/L [126-135 mg/dL]: -10.8 percentage points [95% CI: -14.1 to -7.6; P < .001]). Personal targets >6.5 mmol/L (117 mg/dL) were associated with significantly lower time (<3.9 mmol/L [<70 mg/dL]; 6.5-7.0 mmol/L [117-126 mg/dL]: -1.85 percentage points [95% CI: -2.37 to -1.34; P < .001]; 7.0-7.5 mmol/L [126-135 mg/dL]: -2.68 percentage points [95% CI: -3.49 to -1.86; P < .001]).

CONCLUSIONS

Discrete study populations showed differences in glucose control when applying similar personal targets.

Interest & Impact

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