Coluccia, Achille; Matti, Fabienne; Zhu, Xilei; Lussi, Adrian; Stähli, Alexandra; Sculean, Anton; Eick, Sigrun (2022). In Vitro Study on Green Propolis as a Potential Ingredient of Oral Health Care Products. Antibiotics, 11(12) MDPI 10.3390/antibiotics11121764
|
Text
antibiotics-11-01764-v2.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
Propolis is increasingly being discussed as an alternative to commonly used antiseptics. This in vitro study focused on the ethanolic extract of green Brazilian propolis (EEPg) as an additive in an oral health care product. We investigated (i) a potential inflammation-modulation activity of EEPg when a periodontal or Candida biofilm was exposed to monocytic (MONO-MAC-6) cells, (ii) the adhesion of oral pathogens to gingival keratinocytes and (iii) the antimicrobial and antibiofilm effect of different toothpaste formulations. EEPg decreased the levels of interleukin (IL)-1β and increased IL-10 in MONO-MAC cells challenged with a periodontal biofilm. In contact with TIGK cells, EEPg reduced the numbers of adherent Porphyromonas gingivalis to 0.5% but did not affect the adhesion of Candida albicans. The frequent brushing of a cariogenic biofilm with a toothpaste supplemented with EEPg reduced the surface microhardness loss of enamel specimens. Mixing an experimental erythritol toothpaste with 25 and 50 mg/mL of EEPg confirmed the antibacterial activity of EEPg against oral bacteria and particularly inhibited periodontal biofilm formation. The suggested toothpaste formulations seem to have potential in the prevention of caries, gingivitis and periodontitis and should be evaluated in further in vitro research and in clinical trials.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology 04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry 04 Faculty of Medicine > School of Dental Medicine |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Zhu, Xilei, Lussi, Adrian, Stähli, Alexandra Beatrice, Sculean, Anton, Eick, Sigrun |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2079-6382 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
06 Jan 2023 14:12 |
Last Modified: |
09 Aug 2023 18:28 |
Publisher DOI: |
10.3390/antibiotics11121764 |
PubMed ID: |
36551420 |
Uncontrolled Keywords: |
Brazilian green propolis biofilm monocytic cells toothpaste |
BORIS DOI: |
10.48350/176511 |
URI: |
https://boris.unibe.ch/id/eprint/176511 |
Actions (login required)
 |
Edit item |