Haute, Gabriela Viegas; Luft, Carolina; Pedrazza, Leonardo; Antunes, Géssica Luana; Silveira, Josiane; de Souza Basso, Bruno; Levorse, Vitor Giancarlo Schneider; Bastos, Matheus Scherer; Melo, Denizar; Rodrigues, Ketlin Fernanda; Garcia, Maria Claudia; da Costa, Mariana Severo; Matzenbacher, Lucas Strasburger; Kaiber, Daniela Benvenutti; Donadio, Márcio Vinícius Fagundes; Gracia-Sancho, Jordi; de Oliveira, Jarbas Rodrigues (2023). Simvastatin attenuates inflammatory process on LPS-induced acute lung injury in mice. Respiratory physiology & neurobiology, 309(104002), p. 104002. Elsevier 10.1016/j.resp.2022.104002
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Acute lung injury (ALI) is a disease of high prevalence and is characterized by the excessive production of inflammatory mediators in the lungs of people sick. Inflammation is the major characteristic of ALI and studies report that inhibition of inflammatory cytokines could be an alternative treatment. Statins such as Simvastatin (SV) are known to their use for cholesterol reduction but also for inflammatory and immunoregulatory processes. In this study, we evaluated the effects of SV on LPS-induced alveolar macrophages and in ALI mice model. Our study has demonstrated the protective effects of SV on LPS-activated alveolar macrophages RAW 264.7 and LPS-induced ALI in mice. SV treatment significantly inhibited the alveolar macrophages activation by decreasing the iNOS, IL-1β, and IL-6 gene expression in vitro and in vivo. The treatment also decreased the inflammatory cells migration and the cytokines gene expression. Our findings suggest that SV can act as an anti-inflammatory agent for acute lung injury.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology |
UniBE Contributor: |
Jordi, Gracia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1569-9048 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 Jan 2023 08:57 |
Last Modified: |
23 Jan 2023 00:15 |
Publisher DOI: |
10.1016/j.resp.2022.104002 |
PubMed ID: |
36566004 |
Uncontrolled Keywords: |
acute lung injury cytokines inflammation macrophages neutrophils simvastatin |
BORIS DOI: |
10.48350/176521 |
URI: |
https://boris.unibe.ch/id/eprint/176521 |
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