The "index vein" as a sign for migraine aura in the emergency setting.

Scutelnic, Adrian; Petroulia, Valentina; Schraml, Lara; Jung, Simon; Branca, Mattia; Beyeler, Morin; Fischer, Urs; Wiest, Roland; Slavova, Nedelina; Schankin, Christoph J (2023). The "index vein" as a sign for migraine aura in the emergency setting. Cephalalgia : an international journal of headache, 43(1), p. 3331024221132010. International Headache Society 10.1177/03331024221132010

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Background and objectives To assess the usefulness of the "index vein" for making the diagnosis of migraine aura.Methods 400 patients were included when they: i) presented with an acute neurological deficit, ii) had a brain MRI, and iii) had a discharge diagnosis of migraine aura, ischemic stroke, epileptic seizure or controls (n = 100 per group).Results Compared to stroke (2%), epileptic seizure (4%) and controls (1%), the index vein is more prevalent in migraine aura (17%, p < 0.001). The index vein is highly specific for migraine aura (specificity 97%, 95% CI 95-99). The index vein has a positive predictive value for the diagnosis of migraine aura of 70% (95%CI 48-87). The index vein-score has the ability to diagnose migraine aura with a sensitivity of 94% (95%CI 87.4-97.8) and specificity of 73.5% (95%CI 66.8-79.5) at a cut-off of 4 points.Discussion The index vein serves as a good biomarker for migraine aura in the emergency setting.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Scutelnic, Adrian, Petroulia, Valentina Dafni, Schraml, Lara Theresa, Jung, Simon, Branca, Mattia, Beyeler, Morin, Fischer, Urs Martin, Wiest, Roland Gerhard Rudi, Schankin, Christoph Josef


600 Technology > 610 Medicine & health




International Headache Society


[4] Swiss National Science Foundation




Pubmed Import

Date Deposited:

11 Jan 2023 11:20

Last Modified:

20 Feb 2024 14:15

Publisher DOI:


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Uncontrolled Keywords:

Index vein epilepsy migraine aura stroke




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