Becchetti, Chiara; Lange, Naomi F; Delgado, Maria Gabriela; Brönnimann, Michael P; Maurer, Martin H; Dufour, Jean-François; Berzigotti, Annalisa (2023). 2D shear wave elastography of the rectus femoris muscle in patients with cirrhosis: feasibility and clinical findings. A pilot study. Clinics and research in hepatology and gastroenterology, 47(3), p. 102080. Elsevier Masson 10.1016/j.clinre.2023.102080
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
1-s2.0-S2210740123000050-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB) |
BACKGROUND AND AIMS
Frailty is frequent in cirrhosis and associated with skeletal muscle abnormalities and worse prognosis. 2D shear-wave elastography (2D-SWE) could mirror biomechanical properties of skeletal muscle reflecting muscle quality. However, there is no data on 2D-SWE on skeletal muscle stiffness assessment in cirrhosis and on frailty.
METHODS
Outpatients with cirrhosis were prospectively included in a single center. Skeletal muscle stiffness was studied at the rectus femoris by 2D-SWE. Ileo-psoas area and index (area/height2), and antero-posterior diameter of rectus femoris (RF) was measured on ultrasound.
RESULTS
We included 44 patients (24 male, age 59 [IQR 49-66]) with a median liver frailty index (LFI) of 3.7 (IQR 3.2-4.0). Measurement of RF muscle stiffness (RFMS) was feasible in all with high inter-measurement reproducibility. RFMS did not correlate with LFI, liver function and skeletal muscle diameters. Ileo-psoas index was lower in frail patients (1.7 vs 1.0 cm2/m2, p=0.024). RF antero-posterior diameter inversely correlated with LFI (r -0.578: p<0.001).
CONCLUSION
RFMS by 2D-SWE is feasible and reproducible in cirrhosis and is independent of liver function and LFI, and warrants further studies in this setting. RF antero-posterior diameter could be reported as an objective parameter mirroring sarcopenia and frailty.
Actions (login required)
 |
Edit item |