2D shear wave elastography of the rectus femoris muscle in patients with cirrhosis: feasibility and clinical findings. A pilot study.

Becchetti, Chiara; Lange, Naomi F; Delgado, Maria Gabriela; Brönnimann, Michael P; Maurer, Martin H; Dufour, Jean-François; Berzigotti, Annalisa (2023). 2D shear wave elastography of the rectus femoris muscle in patients with cirrhosis: feasibility and clinical findings. A pilot study. Clinics and research in hepatology and gastroenterology, 47(3), p. 102080. Elsevier Masson 10.1016/j.clinre.2023.102080

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BACKGROUND AND AIMS

Frailty is frequent in cirrhosis and associated with skeletal muscle abnormalities and worse prognosis. 2D shear-wave elastography (2D-SWE) could mirror biomechanical properties of skeletal muscle reflecting muscle quality. However, there is no data on 2D-SWE on skeletal muscle stiffness assessment in cirrhosis and on frailty.

METHODS

Outpatients with cirrhosis were prospectively included in a single center. Skeletal muscle stiffness was studied at the rectus femoris by 2D-SWE. Ileo-psoas area and index (area/height2), and antero-posterior diameter of rectus femoris (RF) was measured on ultrasound.

RESULTS

We included 44 patients (24 male, age 59 [IQR 49-66]) with a median liver frailty index (LFI) of 3.7 (IQR 3.2-4.0). Measurement of RF muscle stiffness (RFMS) was feasible in all with high inter-measurement reproducibility. RFMS did not correlate with LFI, liver function and skeletal muscle diameters. Ileo-psoas index was lower in frail patients (1.7 vs 1.0 cm2/m2, p=0.024). RF antero-posterior diameter inversely correlated with LFI (r -0.578: p<0.001).

CONCLUSION

RFMS by 2D-SWE is feasible and reproducible in cirrhosis and is independent of liver function and LFI, and warrants further studies in this setting. RF antero-posterior diameter could be reported as an objective parameter mirroring sarcopenia and frailty.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

Graduate School:

 Graduate School for Health Sciences (GHS)

UniBE Contributor:

 Becchetti, Chiara, Lange, Naomi Franziska, Delgado, Maria Gabriela, Brönnimann, Michael, Maurer, Martin, Dufour, Jean-François, Berzigotti, Annalisa

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 2210-741X

Publisher:

 Elsevier Masson

Language:

 English

Submitter:

 Pubmed Import

Date Deposited:

 25 Jan 2023 15:54

Last Modified:

 05 Mar 2023 00:16

Publisher DOI:

 10.1016/j.clinre.2023.102080

PubMed ID:

 36657524

Uncontrolled Keywords:

 Liver Frailty Index Liver disease Sarcopenia

BORIS DOI:

 10.48350/177700

URI:

 https://boris.unibe.ch/id/eprint/177700

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