Saliakoura, Maria; Konstantinidou, Georgia (2023). Lipid Metabolic Alterations in KRAS Mutant Tumors: Unmasking New Vulnerabilities for Cancer Therapy. International journal of molecular sciences, 24(2) MDPI 10.3390/ijms24021793
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KRAS is one of the most commonly mutated genes, an event that leads to development of highly aggressive and resistant to any type of available therapy tumors. Mutated KRAS drives a complex network of lipid metabolic rearrangements to support the adaptation of cancer cells to harsh environmental conditions and ensure their survival. Because there has been only a little success in the continuous efforts of effectively targeting KRAS-driven tumors, it is of outmost importance to delineate the exact mechanisms of how they get rewired, leading to this distinctive phenotype. Therefore, the aim of this review is to summarize the available data acquired over the last years with regard to the lipid metabolic regulation of KRAS-driven tumors and elucidate their specific characteristics in an attempt to unravel novel therapeutic targets.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Saliakoura, Maria, Konstantinidou, Georgia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1422-0067 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Jan 2023 12:51 |
Last Modified: |
27 Jan 2023 06:07 |
Publisher DOI: |
10.3390/ijms24021793 |
PubMed ID: |
36675307 |
Uncontrolled Keywords: |
KRAS-driven tumors cancer therapy lipid metabolism tumor vulnerabilities |
BORIS DOI: |
10.48350/177758 |
URI: |
https://boris.unibe.ch/id/eprint/177758 |
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