Enhanced Drug Delivery for Cardiac Microvascular Obstruction with an Occlusion-Infusion-Catheter.

Rösch, Yannick; Eggenberger, David; Kuster, Yves; Widmer, Lino; Frey, Sabrina; Schwartz, Rob; Nef, Cornelia; Ulmer, Jens; Obrist, Dominik (2023). Enhanced Drug Delivery for Cardiac Microvascular Obstruction with an Occlusion-Infusion-Catheter. Annals of biomedical engineering, 51(6), pp. 1343-1355. Springer 10.1007/s10439-023-03142-z

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Microvascular Obstruction (MVO) is a common consequence of acute myocardial infarction. MVO is underdiagnosed and treatment is often nonspecific and ineffective. A multi-scale in-vitro benchtop model was established to investigate drug perfusion in MVO affected microcirculation. The central element of the benchtop model was a fluidic microchip containing channels with diameters between [Formula: see text] and 50 μm representing [Formula: see text] of the microvascular tree fed by the left anterior descending artery (LAD). The outlets of the chip could be closed to mimic MVO. Two methods for intracoronary infusion of pharmacologic agents (simulated by dye) to regions with MVO were investigated using an occlusion-infusion catheter. The first case was a simple, bolus-like infusion into the LAD, whereas the second case consisted of infusion with concomitant proximal occlusion of the LAD phantom with a balloon. Results show that local dye concentration maxima in the chip with MVO were 2.2-3.2 times higher for the case with proximal balloon occlusion than for the conventional infusion method. The cumulated dose could be raised by a factor 4.6-5.2. These results suggest that drug infusion by catheter is more effective if the blood supply to the treated vascular bed is temporarily blocked by a balloon catheter.

Item Type:

Journal Article (Original Article)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Rösch, Yannick Pascal, Widmer, Lino, Obrist, Dominik

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0090-6964

Publisher:

Springer

Language:

English

Submitter:

Pubmed Import

Date Deposited:

23 Jan 2023 12:14

Last Modified:

12 May 2023 00:13

Publisher DOI:

10.1007/s10439-023-03142-z

PubMed ID:

36681747

Uncontrolled Keywords:

Balloon occlusion Controlled flow infusion Coronary circulation Intracoronary drug infusion Left-heart mock loop MVO Microfluidic chip STEMI

BORIS DOI:

10.48350/177768

URI:

https://boris.unibe.ch/id/eprint/177768

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