Alcohol Biomarker Phosphatidylethanol as a Predictor of the Severity of Alcohol Withdrawal Syndrome.

Novak, Lan; Soravia, Leila M; Bünter, Adina; Stöth, Frederike; Wopfner, Alexander; Weinmann, Wolfgang; Pfeifer, Philippe (2023). Alcohol Biomarker Phosphatidylethanol as a Predictor of the Severity of Alcohol Withdrawal Syndrome. Alcohol and alcoholism, 58(2), pp. 198-202. Oxford University Press 10.1093/alcalc/agac071

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AIMS

to investigate the relationship between phosphatidylethanol (PEth) and withdrawal severity in patients with alcohol use disorder (AUD).

METHODS

in 34 patients with AUD admitted for treatment of acute alcohol withdrawal, data were available for initial blood PEth concentrations and scores throughout detoxification of symptoms of withdrawal assessed by trained medical staff using the alcohol withdrawal syndrome (AWS)-scale, a validated scale consisting of 11 items in the alcohol withdrawal syndrome (two subscales with seven physiological and five psychological symptoms).

RESULTS

a significant positive correlation between PEth and the severity of alcohol withdrawal was found. When the sample was divided into two groups, according to whether or not AWS score at some point in the treatment reached 6 or more, the median PEth score was higher in those whose peak score had been 6 or more (score of 6 being the suggested cutoff to start medicating the withdrawal syndrome). Although there was a trend for some aspects of the clinical history to be more 'severe' in those with higher AWS, no differences reached significance.

CONCLUSION

blood PEth on admission could have a role in identifying patients at risk of more severe AWS.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center 04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology
Graduate School:	Graduate School for Cellular and Biomedical Sciences (GCB)
UniBE Contributor:	Soravia Bachofner, Leila Maria, Stöth, Frederike Theresa, Weinmann, Wolfgang, Pfeifer, Philippe
Subjects:	600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services
ISSN:	0735-0414
Publisher:	Oxford University Press
Language:	English
Submitter:	Pubmed Import
Date Deposited:	27 Jan 2023 14:10
Last Modified:	27 Apr 2023 15:32
Publisher DOI:	10.1093/alcalc/agac071
PubMed ID:	36695434
Uncontrolled Keywords:	alcohol biomarker alcohol use disorder phosphatidylethanol withdrawal
URI:	https://boris.unibe.ch/id/eprint/177906