Renggli, Luzia; Gasser, Michael; Buetti, Niccolò; Kronenberg, Andreas (2023). Increase in methicillin-susceptible Staphylococcus aureus bloodstream infections in Switzerland: a nationwide surveillance study (2008-2021). Infection, 51(4), pp. 1025-1031. Springer 10.1007/s15010-023-01980-6
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PURPOSE
An increasing burden of Staphylococcus aureus bloodstream infections (BSI), despite a decrease in the percentage of methicillin-resistant S. aureus (MRSA), was described recently in other European countries. The main aim of this study was to analyse recent temporal trends of S. aureus, methicillin-susceptible S. aureus (MSSA) and MRSA BSI for Switzerland as well as the different linguistic regions within Switzerland. An additional aim was to estimate potential differences among patient-based and epidemiological risk factors.
METHODS
A retrospective observational study was conducted in Switzerland over a period of 14 years (2008-2021). Trends in S. aureus, MSSA and MRSA BSI were analysed by applying linear regression models.
RESULTS
Staphylococcus aureus BSI increased by + 30% from 19.7 to 25.6 cases per 100,000 inhabitants between 2008 and 2021 (P < 0.01) in Switzerland. Thereof, MSSA increased by + 37% from 17.8 to 24.4 cases per 100,000 inhabitants (P < 0.01). MRSA decreased from 1.9 to 1.2 cases per 100,000 inhabitants (P < 0.01), which was driven by decreasing incidence in the French-speaking region. MSSA BSI increased significantly (P < 0.01) in both linguistic regions. A further stratification revealed that incidence increased the most in male patients of the age group ≥ 80 years of the German-speaking region.
CONCLUSION
The increasing health burden of MSSA BSI in Switzerland indicates that not only proportions of resistant microorganisms but also total BSI incidences should be monitored. In addition, data stratification revealed that the increase was mainly driven by an increasing incidence in elderly males of the German-speaking region.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Renggli, Luzia Sonja, Gasser, Michael, Kronenberg, Andreas Oskar |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1439-0973 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
07 Feb 2023 10:08 |
Last Modified: |
19 Jul 2023 00:12 |
Publisher DOI: |
10.1007/s15010-023-01980-6 |
PubMed ID: |
36732413 |
Uncontrolled Keywords: |
Bacteraemia Methicillin-resistant Staphylococcus aureus bloodstream infections Methicillin-susceptible Staphylococcus aureus Switzerland |
BORIS DOI: |
10.48350/178331 |
URI: |
https://boris.unibe.ch/id/eprint/178331 |
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