Effect of electroporation-mediated diphtheria toxin A expression on PSA positive human prostate xenograft tumors in SCID mice

Goepfert, Christine; Gazdhar, Amiq; Frey, Felix J; Frey, Brigitte M (2011). Effect of electroporation-mediated diphtheria toxin A expression on PSA positive human prostate xenograft tumors in SCID mice. Prostate, 71(8), pp. 872-80. Hoboken, N.J.: Wiley-Blackwell 10.1002/pros.21303

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Current therapies to treat prostate cancer are often limited. Since it has been shown that very low concentrations of diphtheria toxin A (DT-A) result in abrogation of protein synthesis and apoptosis of cells, DT-A might serve as an efficient killer in cancer gene therapy. For this purpose we investigated in a quantitative manner using a stereological approach the apoptotic effect of DT-A in androgen receptor (AR) and prostate specific antigen (PSA) expressing cells after tumor formation in both flanks of SCID mice.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
UniBE Contributor:	Gazdhar, Amiq, Frey, Felix (B), Frey, Brigitte
ISSN:	0270-4137
Publisher:	Wiley-Blackwell
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:11
Last Modified:	29 Mar 2023 23:32
Publisher DOI:	10.1002/pros.21303
PubMed ID:	21456069
Web of Science ID:	000289517500008
URI:	https://boris.unibe.ch/id/eprint/1784 (FactScience: 203810)