Effect of electroporation-mediated diphtheria toxin A expression on PSA positive human prostate xenograft tumors in SCID mice

Goepfert, Christine; Gazdhar, Amiq; Frey, Felix J; Frey, Brigitte M (2011). Effect of electroporation-mediated diphtheria toxin A expression on PSA positive human prostate xenograft tumors in SCID mice. Prostate, 71(8), pp. 872-80. Hoboken, N.J.: Wiley-Blackwell 10.1002/pros.21303

Full text not available from this repository. (Request a copy)

Current therapies to treat prostate cancer are often limited. Since it has been shown that very low concentrations of diphtheria toxin A (DT-A) result in abrogation of protein synthesis and apoptosis of cells, DT-A might serve as an efficient killer in cancer gene therapy. For this purpose we investigated in a quantitative manner using a stereological approach the apoptotic effect of DT-A in androgen receptor (AR) and prostate specific antigen (PSA) expressing cells after tumor formation in both flanks of SCID mice.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

Gazdhar, Amiq Ur Rahman; Frey, Felix Julius and Frey, Brigitte

ISSN:

0270-4137

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:11

Last Modified:

06 Dec 2013 13:21

Publisher DOI:

10.1002/pros.21303

PubMed ID:

21456069

Web of Science ID:

000289517500008

URI:

https://boris.unibe.ch/id/eprint/1784 (FactScience: 203810)

Actions (login required)

Edit item Edit item
Provide Feedback