Usefulness and Reliability of the Bispectral Index during Balanced Anesthesia for Neurovascular Surgery in New Zealand White Rabbits

Petrucci, Mariafrancesca; Spadavecchia, Claudia; Wanderer, Stefan; Boillat, Gwendoline; Marbacher, Serge; Garcia Casalta, Luisana Gisela; Casoni, Daniela (2023). Usefulness and Reliability of the Bispectral Index during Balanced Anesthesia for Neurovascular Surgery in New Zealand White Rabbits. Brain Sciences, 13(327), pp. 1-15. MDPI 10.3390/brainsci13020327

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Few data about the electroencephalogram and its calculated indices, such as the bispectral index (BIS), have been reported in rabbits. We aimed to evaluate whether a clinically stable anesthesia was mirrored by consistent and stable BIS values and to investigate the effects of modified cerebral blood supply, due to bilateral carotid clamping and re-opening, on BIS values. We also investigated the effects of fentanyl, as an antinociceptive drug, on the BIS. Sixty-eight rabbits undergoing general anesthesia for surgical creation of carotid bifurcation aneurysms were enrolled. The BIS values were recorded at nine selected time points (TPs) during each procedure and before and after fentanyl administration. The BIS values over time were compared with two-way repeated-measures analysis of variance followed by Tukey test, while the Wilcoxon signed rank test was performed to compare values at clamping and re-opening of the carotids as well as before and after fentanyl administration. The BIS values were significantly lower during anesthesia than at the end of anesthesia and at tracheal extubation; no significant differences were found among other TPs. Adequate depth of anesthesia was mirrored by consistent BIS values among rabbits, and alteration of cerebral blood supply did not modify BIS values, except once. Following fentanyl, BIS values did not change in a clinically relevant way.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Services > ESI
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology

UniBE Contributor:

Petrucci, Mariafrancesca, Spadavecchia, Claudia, Wanderer, Stefan, Marbacher, Serge, Garcia Casalta, Luisana Gisela, Casoni, Daniela

Subjects:

600 Technology > 630 Agriculture
600 Technology > 610 Medicine & health

ISSN:

2076-3425

Publisher:

MDPI

Language:

English

Submitter:

Mariafrancesca Petrucci

Date Deposited:

15 Feb 2023 08:40

Last Modified:

15 Feb 2023 23:28

Publisher DOI:

10.3390/brainsci13020327

Uncontrolled Keywords:

bispectral index; balanced anesthesia; neuromonitoring; neurosurgery; rabbits; fentanyl; carotid bifurcation; experimental anesthesia

BORIS DOI:

10.48350/178794

URI:

https://boris.unibe.ch/id/eprint/178794

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