Determining the optical properties of a gelatin-TiO2 phantom at 780 nm

Akarçay, Hidayet Günhan; Preisser, Stefan; Frenz, Martin; Ricka, Jaro (2012). Determining the optical properties of a gelatin-TiO2 phantom at 780 nm. Biomedical optics express, 3(3), pp. 418-434. Washington, D.C.: Optical Society of America 10.1364/BOE.3.000418

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Tissue phantoms play a central role in validating biomedical imaging techniques. Here we employ a series of methods that aim to fully determine the optical properties, i.e., the refractive index n, absorption coefficient μa, transport mean free path ℓ∗, and scattering coefficient μs of a TiO2 in gelatin phantom intended for use in optoacoustic imaging. For the determination of the key parameters μa and ℓ∗, we employ a variant of time of flight measurements, where fiber optodes are immersed into the phantom to minimize the influence of boundaries. The robustness of the method was verified with Monte Carlo simulations, where the experimentally obtained values served as input parameters for the simulations. The excellent agreement between simulations and experiments confirmed the reliability of the results. The parameters determined at 780 nm are n=1.359(±0.002), μ′s=1/ℓ∗=0.22(±0.02) mm-1, μa= 0.0053(+0.0006-0.0003) mm-1, and μs=2.86(±0.04) mm-1. The asymmetry parameter g obtained from the parameters ℓ∗ and μ′s is 0.93, which indicates that the scattering entities are not bare TiO2 particles but large sparse clusters. The interaction between the scattering particles and the gelatin matrix should be taken into account when developing such phantoms.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics

UniBE Contributor:

Akarçay, Hidayet Günhan; Preisser, Stefan; Frenz, Martin and Ricka, Jaroslav

Subjects:

600 Technology > 620 Engineering

ISSN:

2156-7085

Publisher:

Optical Society of America

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:43

Last Modified:

09 Dec 2014 14:36

Publisher DOI:

10.1364/BOE.3.000418

Web of Science ID:

000302787000005

BORIS DOI:

10.7892/boris.17907

URI:

https://boris.unibe.ch/id/eprint/17907 (FactScience: 225744)

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