Ravindra, Kodihalli C; Vaidya, Vishal S; Wang, Zhenyu; Federspiel, Joel D; Virgen-Slane, Richard; Everley, Robert A; Grove, Jane I; Stephens, Camilla; Ocana, Mireia F; Robles-Díaz, Mercedes; Isabel Lucena, M; Andrade, Raul J; Atallah, Edmond; Gerbes, Alexander L; Weber, Sabine; Cortez-Pinto, Helena; Fowell, Andrew J; Hussaini, Hyder; Bjornsson, Einar S; Patel, Janisha; ... (2023). Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans. Nature communications, 14(1), p. 1215. Nature Publishing Group 10.1038/s41467-023-36858-6
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Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in patients with DILI at onset (DO; n = 133) and follow-up (n = 120), acute non-DILI at onset (NDO; n = 63) and follow-up (n = 42), and healthy volunteers (HV; n = 104). Area under the receiver operating characteristic curve (AUC) for cytoplasmic aconitate hydratase, argininosuccinate synthase, carbamoylphosphate synthase, fumarylacetoacetase, fructose-1,6-bisphosphatase 1 (FBP1) across cohorts achieved near complete separation (range: 0.94-0.99) of DO and HV. In addition, we show that FBP1, alone or in combination with glutathione S-transferase A1 and leukocyte cell-derived chemotaxin 2, could potentially assist in clinical diagnosis by distinguishing NDO from DO (AUC range: 0.65-0.78), but further technical and clinical validation of these candidate biomarkers is needed.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Stirnimann, Guido |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2041-1723 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
06 Mar 2023 13:39 |
Last Modified: |
12 Mar 2023 02:16 |
Publisher DOI: |
10.1038/s41467-023-36858-6 |
PubMed ID: |
36869085 |
BORIS DOI: |
10.48350/179502 |
URI: |
https://boris.unibe.ch/id/eprint/179502 |
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