Muri, Jonathan; Cecchinato, Valentina; Cavalli, Andrea; Shanbhag, Akanksha A; Matkovic, Milos; Biggiogero, Maira; Maida, Pier Andrea; Moritz, Jacques; Toscano, Chiara; Ghovehoud, Elaheh; Furlan, Raffaello; Barbic, Franca; Voza, Antonio; De Nadai, Guendalina; Cervia, Carlo; Zurbuchen, Yves; Taeschler, Patrick; Murray, Lilly A; Danelon-Sargenti, Gabriela; Moro, Simone; ... (2023). Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course. Nature immunology, 24(4), pp. 604-611. Nature Publishing Group 10.1038/s41590-023-01445-w
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Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. Here we discovered that antibodies against specific chemokines were omnipresent post-COVID-19, were associated with favorable disease outcome and negatively correlated with the development of long COVID at 1 yr post-infection. Chemokine antibodies were also present in HIV-1 infection and autoimmune disorders, but they targeted different chemokines compared with COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bound to the chemokine N-loop impaired cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising chemokine antibodies may modulate the inflammatory response and thus bear therapeutic potential.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Rauch, Andri |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1529-2908 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
07 Mar 2023 11:26 |
Last Modified: |
01 Apr 2023 00:15 |
Publisher DOI: |
10.1038/s41590-023-01445-w |
PubMed ID: |
36879067 |
BORIS DOI: |
10.48350/179605 |
URI: |
https://boris.unibe.ch/id/eprint/179605 |
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