Multidisciplinary recommendations for essential baseline functional and laboratory tests to facilitate early diagnosis and management of immune-related adverse events among cancer patients.

Özdemir, Berna C; Espinosa da Silva, Cristina; Arangalage, Dimitri; Monney, Pierre; Guler, Sabina A; Huynh-Do, Uyen; Stirnimann, Guido; Possamai, Lucia; Trepp, Roman; Hoepner, Robert; Salmen, Anke; Gerard, Camille L; Hruz, Petr; Christ, Lisa; Rothschild, Sacha I (2023). Multidisciplinary recommendations for essential baseline functional and laboratory tests to facilitate early diagnosis and management of immune-related adverse events among cancer patients. Cancer immunology, immunotherapy : CII, 72(7), pp. 1991-2001. Springer 10.1007/s00262-023-03436-0

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Immune checkpoint inhibitors (ICIs) have fundamentally changed the treatment landscape of various cancers. While ICI treatments result in improved survival, quality of life and are cost-effective, the majority of patients experience at least one immune-related adverse event (irAE). Many of these side effects cause little discomfort or are asymptomatic; however, irAEs can affect any organ and are potentially life-threatening. Consequently, early diagnosis and appropriate treatment of irAEs are critical for optimizing long-term outcomes and quality of life in affected patients. Some irAEs are diagnosed according to typical symptoms, others by abnormal findings from diagnostic tests. While there are various guidelines addressing the management of irAEs, recommendations for the early recognition of irAEs as well as the optimal extent and frequency of laboratory tests are mostly lacking. In clinical practice, blood sampling is usually performed before each ICI administration (i.e., every 2-3 weeks), often for several months, representing a burden for patients as well as health care systems. In this report, we propose essential laboratory and functional tests to improve the early detection and management of irAEs and in cancer patients treated with ICIs. These multidisciplinary expert recommendations regarding essential laboratory and functional tests can be used to identify possible irAEs at an early time point, initiate appropriate interventions to improve patient outcomes, and reduce the burden of blood sampling during ICI treatment.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Özdemir, Berna, Guler, Sabina Anna, Huynh-Do, Uyen, Stirnimann, Guido, Trepp, Roman, Hoepner, Robert, Salmen, Anke, Christ, Lisa Alexandra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1432-0851

Publisher:

Springer

Language:

English

Submitter:

Pubmed Import

Date Deposited:

06 Apr 2023 10:40

Last Modified:

14 Jun 2023 00:14

Publisher DOI:

10.1007/s00262-023-03436-0

Related URLs:

PubMed ID:

37017694

Uncontrolled Keywords:

Baseline evaluation Diagnosis Immune checkpoint inhibitors Immune-related adverse events Laboratory tests Minimal data set

BORIS DOI:

10.48350/181547

URI:

https://boris.unibe.ch/id/eprint/181547

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