Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy.

Cusinato, Riccardo; Alnes, Sigurd L; van Maren, Ellen; Boccalaro, Ida; Ledergerber, Debora; Adamantidis, Antoine; Imbach, Lukas L; Schindler, Kaspar; Baud, Maxime O; Tzovara, Athina (2023). Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy. The Journal of neuroscience, 43(20), pp. 3696-3707. Society for Neuroscience 10.1523/JNEUROSCI.1941-22.2023

Preview

Text JNEUROSCI.1941-22.2023.full.pdf - Accepted Version Available under License Publisher holds Copyright. Download (1MB) | Preview

During rest, intrinsic neural dynamics manifest at multiple timescales, which progressively increase along visual and somatosensory hierarchies. Theoretically, intrinsic timescales are thought to facilitate processing of external stimuli at multiple stages. However, direct links between timescales at rest and sensory processing, as well as translation to the auditory system are lacking. Here, we measured intracranial electroencephalography in 11 human patients with epilepsy (4 women), while listening to pure tones. We show that in the auditory network, intrinsic neural timescales progressively increase, while the spectral exponent flattens, from temporal to entorhinal cortex, hippocampus, and amygdala. Within the neocortex, intrinsic timescales exhibit spatial gradients that follow the temporal lobe anatomy. Crucially, intrinsic timescales at baseline can explain the latency of auditory responses: as intrinsic timescales increase, so do the single-electrode response onset and peak latencies. Our results suggest that the human auditory network exhibits a repertoire of intrinsic neural dynamics, which manifest in cortical gradients with millimeter resolution and may provide a variety of temporal windows to support auditory processing.SIGNIFICANCE STATEMENT:Endogenous neural dynamics are often characterized by their intrinsic timescales. These are thought to facilitate processing of external stimuli. However, a direct link between intrinsic timing at rest and sensory processing is missing. Here, with intracranial electroencephalography (iEEG), we show that intrinsic timescales progressively increase from temporal to entorhinal cortex, hippocampus, and amygdala. Intrinsic timescales at baseline can explain the variability in the timing of iEEG responses to sounds: cortical electrodes with fast timescales also show fast and short-lasting responses to auditory stimuli, which progressively increase in the hippocampus and amygdala. Our results suggest that a hierarchy of neural dynamics in the temporal lobe manifests across cortical and limbic structures and can explain the temporal richness of auditory responses.

Interest & Impact

Downloads

146 since deposited on 13 Apr 2023
73 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item