The Risk of Recurrence in Endometrial Cancer Patients with Low-Volume Metastasis in the Sentinel Lymph Nodes: A Retrospective Multi-Institutional Study.

Buda, Alessandro; Paniga, Cristiana; Taskin, Salih; Mueller, Michael; Zapardiel, Ignacio; Fanfani, Francesco; Puppo, Andrea; Casarin, Jvan; Papadia, Andrea; De Ponti, Elena; Grassi, Tommaso; Mauro, Jessica; Turan, Hasan; Vatansever, Dogan; Gungor, Mete; Ortag, Firat; Imboden, Sara; Garcia-Pineda, Virginia; Mohr, Stefan; Siegenthaler, Franziska; ... (2023). The Risk of Recurrence in Endometrial Cancer Patients with Low-Volume Metastasis in the Sentinel Lymph Nodes: A Retrospective Multi-Institutional Study. Cancers, 15(7) MDPI AG 10.3390/cancers15072052

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The aim of this study was to assess the impact of low-volume metastasis (LVM) on disease-free survival (DFS) in women with apparent early-stage endometrial cancer (EC) who underwent sentinel lymph node (SLN) mapping. Patients with pre-operative early-stage EC were retrospectively collected from an international collaboration including 13 referring institutions. A total of 1428 patients were included in this analysis. One hundred and eighty-six patients (13%) had lymph node involvement. Fifty-nine percent of positive SLN exhibited micrometastases, 26.9% micrometastases, and 14% isolated tumor cells. Seventeen patients with positive lymph nodes did not receive any adjuvant therapy. At a median follow-up of 33.3 months, the disease had recurred in 114 women (8%). Patients with micrometastases in the lymph nodes had a worse prognosis of disease-free survival compared to patients with negative nodes or LVM. The rate of recurrence was significantly higher for women with micrometastases than those with low-volume metastases (HR = 2.61; p = 0.01). The administration of adjuvant treatment in patients with LVM, without uterine risk factors, remains a matter of debate and requires further evaluation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Mueller, Michael, Imboden, Sara, Siegenthaler, Franziska Anna

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2072-6694

Publisher:

MDPI AG

Language:

English

Submitter:

Pubmed Import

Date Deposited:

14 Apr 2023 11:51

Last Modified:

15 Apr 2023 15:19

Publisher DOI:

10.3390/cancers15072052

PubMed ID:

37046712

Uncontrolled Keywords:

endometrial cancer low-volume metastasis recurrence-free survival sentinel lymph node biopsy ultrastaging

BORIS DOI:

10.48350/181710

URI:

https://boris.unibe.ch/id/eprint/181710

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