Buda, Alessandro; Paniga, Cristiana; Taskin, Salih; Mueller, Michael; Zapardiel, Ignacio; Fanfani, Francesco; Puppo, Andrea; Casarin, Jvan; Papadia, Andrea; De Ponti, Elena; Grassi, Tommaso; Mauro, Jessica; Turan, Hasan; Vatansever, Dogan; Gungor, Mete; Ortag, Firat; Imboden, Sara; Garcia-Pineda, Virginia; Mohr, Stefan; Siegenthaler, Franziska; ... (2023). The Risk of Recurrence in Endometrial Cancer Patients with Low-Volume Metastasis in the Sentinel Lymph Nodes: A Retrospective Multi-Institutional Study. Cancers, 15(7) MDPI AG 10.3390/cancers15072052
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The aim of this study was to assess the impact of low-volume metastasis (LVM) on disease-free survival (DFS) in women with apparent early-stage endometrial cancer (EC) who underwent sentinel lymph node (SLN) mapping. Patients with pre-operative early-stage EC were retrospectively collected from an international collaboration including 13 referring institutions. A total of 1428 patients were included in this analysis. One hundred and eighty-six patients (13%) had lymph node involvement. Fifty-nine percent of positive SLN exhibited micrometastases, 26.9% micrometastases, and 14% isolated tumor cells. Seventeen patients with positive lymph nodes did not receive any adjuvant therapy. At a median follow-up of 33.3 months, the disease had recurred in 114 women (8%). Patients with micrometastases in the lymph nodes had a worse prognosis of disease-free survival compared to patients with negative nodes or LVM. The rate of recurrence was significantly higher for women with micrometastases than those with low-volume metastases (HR = 2.61; p = 0.01). The administration of adjuvant treatment in patients with LVM, without uterine risk factors, remains a matter of debate and requires further evaluation.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Mueller, Michael, Imboden, Sara, Siegenthaler, Franziska Anna |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
14 Apr 2023 11:51 |
Last Modified: |
15 Apr 2023 15:19 |
Publisher DOI: |
10.3390/cancers15072052 |
PubMed ID: |
37046712 |
Uncontrolled Keywords: |
endometrial cancer low-volume metastasis recurrence-free survival sentinel lymph node biopsy ultrastaging |
BORIS DOI: |
10.48350/181710 |
URI: |
https://boris.unibe.ch/id/eprint/181710 |
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