Kirundi, Jorum; Moghadamrad, Sheida; Urbaniak, Camilla (2023). Microbiome-liver crosstalk: A multihit therapeutic target for liver disease. World journal of gastroenterology, 29(11), pp. 1651-1668. WJG Press 10.3748/wjg.v29.i11.1651
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Liver disease has become a leading cause of death, particularly in the West, where it is attributed to more than two million deaths annually. The correlation between gut microbiota and liver disease is still not fully understood. However, it is well known that gut dysbiosis accompanied by a leaky gut causes an increase in lipopolysaccharides in circulation, which in turn evoke massive hepatic inflammation promoting liver cirrhosis. Microbial dysbiosis also leads to poor bile acid metabolism and low short-chain fatty acids, all of which exacerbate the inflammatory response of liver cells. Gut microbial homeostasis is maintained through intricate processes that ensure that commensal microbes adapt to the low oxygen potential of the gut and that they rapidly occupy all the intestinal niches, thus outcompeting any potential pathogens for available nutrients. The crosstalk between the gut microbiota and its metabolites also guarantee an intact gut barrier. These processes that protect against destabilization of gut microbes by potential entry of pathogenic bacteria are collectively called colonization resistance and are equally essential for liver health. In this review, we shall investigate how the mechanisms of colonization resistance influence the liver in health and disease and the microbial-liver crosstalk potential as therapeutic target areas.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Services > CMF |
UniBE Contributor: |
Kirundi, Jorum |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1007-9327 |
Publisher: |
WJG Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Apr 2023 13:05 |
Last Modified: |
22 Apr 2023 15:20 |
Publisher DOI: |
10.3748/wjg.v29.i11.1651 |
PubMed ID: |
37077519 |
Uncontrolled Keywords: |
Gut homeostasis Liver disease Microbial metabolites Microbiome Microbiome-host crosstalk Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis |
BORIS DOI: |
10.48350/181877 |
URI: |
https://boris.unibe.ch/id/eprint/181877 |
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