Wartenberg, Martin; Hool, Sara-Lynn; Marrazzini, Andrea; Giger, Roland; Rupp, Niels J (2023). Differentiated Papillary NUT Carcinoma: An Unexpected, Deceptively Bland Presentation of a Sinonasal Carcinoma. Head and neck pathology, 17(3), pp. 803-807. Springer 10.1007/s12105-023-01554-w
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BACKGROUND
In recent years, the list of tumor entities in the sinonasal tract has significantly expanded, requiring advanced diagnostic testing. We report the case of a 32-year-old patient with an unusual NUT carcinoma originating in the maxillary sinus, which showed extensive well-differentiated, papillary squamous morphology, similar to the spectrum of the recently described DEK::AFF2 fusion-associated carcinoma.
METHODS
We performed immunohistochemical and molecular studies including EBV- and HPV-testing, as well as DNA/RNA next generation sequencing.
RESULTS
The tumor showed predominantly exophytic papillary growth with mature squamous differentiation. An additional component harbored atypical, less differentiated basaloid tumor cells with infiltration of the adjacent stroma. Conspicuous inflammation was evident. There was no evidence of HPV DNA or EBV RNA. Next-generation sequencing revealed a NUT::NSD3 gene fusion corresponding to ("speckled-type") immunopositivity of NUT in the tumor cells.
CONCLUSIONS
We describe a NUT::NSD3 gene fusion-associated NUT carcinoma of the sinonasal tract with a deceptively well-differentiated papillary growth pattern, thus expanding the morphological spectrum of this typically poorly differentiated neoplasm.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Wartenberg, Martin, Hool, Sara-Lynn, Marrazzini, Andrea, Giger, Roland |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
1936-0568 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
01 May 2023 11:14 |
Last Modified: |
22 Sep 2023 00:12 |
Publisher DOI: |
10.1007/s12105-023-01554-w |
PubMed ID: |
37118352 |
Uncontrolled Keywords: |
DEK::AFF2 carcinoma EBV- and HPV-associated carcinomas NUT carcinoma Undifferentiated as well as SWI/SNF complex deficient sinonasal carcinomas |
BORIS DOI: |
10.48350/182114 |
URI: |
https://boris.unibe.ch/id/eprint/182114 |
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