Famularo, Simone; Bannone, Elisa; Collins, Toby; Reitano, Elisa; Okamoto, Nariaki; Mishima, Kohei; Riva, Pietro; Tsai, Yu-Chieh; Nkusi, Richard; Hostettler, Alexandre; Marescaux, Jacques; Felli, Eric; Diana, Michele (2023). Partial Hepatic Vein Occlusion and Venous Congestion in Liver Exploration Using a Hyperspectral Camera: A Proposal for Monitoring Intraoperative Liver Perfusion. Cancers, 15(8) MDPI AG 10.3390/cancers15082397
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INTRODUCTION
The changes occurring in the liver in cases of outflow deprivation have rarely been investigated, and no measurements of this phenomenon are available. This investigation explored outflow occlusion in a pig model using a hyperspectral camera.
METHODS
Six pigs were enrolled. The right hepatic vein was clamped for 30 min. The oxygen saturation (StO2%), deoxygenated hemoglobin level (de-Hb), near-infrared perfusion (NIR), and total hemoglobin index (THI) were investigated at different time points in four perfused lobes using a hyperspectral camera measuring light absorbance between 500 nm and 995 nm. Differences among lobes at different time points were estimated by mixed-effect linear regression.
RESULTS
StO2% decreased over time in the right lateral lobe (RLL, totally occluded) when compared to the left lateral (LLL, outflow preserved) and the right medial (RML, partially occluded) lobes (p < 0.05). De-Hb significantly increased after clamping in RLL when compared to RML and LLL (p < 0.05). RML was further analyzed considering the right portion (totally occluded) and the left portion of the lobe (with an autonomous draining vein). StO2% decreased and de-Hb increased more smoothly when compared to the totally occluded RLL (p < 0.05).
CONCLUSIONS
The variations of StO2% and deoxy-Hb could be considered good markers of venous liver congestion.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Felli, Eric |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 May 2023 11:33 |
Last Modified: |
21 Dec 2023 15:19 |
Publisher DOI: |
10.3390/cancers15082397 |
PubMed ID: |
37190325 |
Uncontrolled Keywords: |
hepatic vein occlusion hyperspectral camera liver congestion liver perfusion liver surgery outflow occlusion |
BORIS DOI: |
10.48350/182630 |
URI: |
https://boris.unibe.ch/id/eprint/182630 |
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