Tsochatzis, Emmanuel A; Watt, Kymberly D; VanWagner, Lisa B; Verna, Elizabeth C; Berzigotti, Annalisa (2023). Evaluation of recipients with significant comorbidity - Patients with cardiovascular disease. Journal of hepatology, 78(6), pp. 1089-1104. Elsevier 10.1016/j.jhep.2023.03.023
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Liver transplant(ation) (LT) is the most effective treatment for patients with decompensated liver disease. The increasing prevalence of obesity and type 2 diabetes and the growing number of patients with non-alcoholic fatty liver disease being evaluated for LT, have resulted in a greater proportion of LT candidates presenting with a higher risk of cardiovascular disease. As cardiovascular disease is a major cause of morbidity and mortality after LT, a thorough cardiovascular evaluation pre-LT is crucial. In this review, we discuss the latest evidence on the cardiovascular evaluation of LT candidates and we focus on the most prevalent conditions, namely ischaemic heart disease, atrial fibrillation and other arrhythmias, valvular heart disease, and cardiomyopathies. LT candidates undergo an electrocardiogram, a resting transthoracic echocardiography and an assessment of their cardiopulmonary functional ability as part of their standardised pre-LT work-up. Further diagnostic work-up is undertaken based on the results of the baseline evaluation and may include a coronary computed tomography angiography in patients with cardiovascular risk factors. The evaluation of potential LT candidates for cardiovascular disease requires a multidisciplinary approach, with input from anaesthetists, cardiologists, hepatologists and transplant surgeons.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology |
UniBE Contributor: |
Berzigotti, Annalisa |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1600-0641 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
22 May 2023 11:47 |
Last Modified: |
22 May 2023 11:56 |
Publisher DOI: |
10.1016/j.jhep.2023.03.023 |
PubMed ID: |
37208096 |
Uncontrolled Keywords: |
MELD NAFLD cardiomyopathy cardiopulmonary reserve cirrhosis ischaemic heart disease liver transplantation type II diabetes |
BORIS DOI: |
10.48350/182709 |
URI: |
https://boris.unibe.ch/id/eprint/182709 |
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